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The Terpenes in the Cannabis Plant

By – Jahan Marcu, Science EditorThere are numerous references in popular Cannabis literature which claim that Cannabis strains can smell like mango, melon, and even grapes. Well, it might not be their imagination. The odor of cannabis comes from over 120 terpenes (a.k.a. terpenoids fragrance molecules) that are made by the plant(1).Continue reading full article at cannabination.com

WNYC, the local public radio station for America’s biggest metropolis, trained their microphones on the police practices concerning marijuana arrests. NYC has the dubious distinction of having the greatest number of marijuana arrests for any locality – it surpasses many whole states. Still, the urban police practice of targeting young, African-American marijuana consumers is not isolated to the Big Apple. Similar racial disparities exist in Philadelphia and likely in most other large cities.

Dr. Harry Levine with the Drug Policy Alliance issued a detailed report about the NYC arrests in March that has spurred increased attention to the issue.  $75 Million a Year: The Cost of New York City’s Marijuana Possession Arrests

The WNYC audio is embedded below but the full text story is also essential reading.

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WNYC: Alleged Illegal Searches by NYPD May Be Increasing Marijuana Arrests

[This is the first story in a two-part series. Read the second part here.]

Police arrest 140 people every day in New York City for possessing small amounts of marijuana. It’s now by far the most common misdemeanor charge in the city, and thousands of these arrests take place when police stop-and-frisk young men in the poorest neighborhoods. While police say these stop-and-frisks are a way to find guns, what they find more often is a bag of marijuana.

An investigation by WNYC suggests that some police officers may be violating people’s constitutional rights when they are making marijuana arrests. Current and former cops, defense lawyers and more than a dozen men arrested for the lowest-level marijuana possession say illegal searches take place during stop-and-frisks, which are street encounters carried out overwhelmingly on blacks and Latinos.  READ FULL STORY

7/7/2011  by Jahan Marcu – The annual International Cannabinoid Research Society (ICRS) meeting is taking place this week in Chicago. I’m here with over 250 researchers to take in 55 presentations on the subject of Cannabis and cannabinoids. This year I’m also honored to be presenting some of my recent work. The ICRS meeting is a unique and concentrated pool of cannabinoid science showcasing the latest breakthroughs.

The morning presentations on the opening day were devoted to the study of cannabinoids in learning and memory.

Indole derivatives such as WIN55212, a compound that is related to JWH-018, may disrupt learning and memory in a way that is much more distinct than THC.

The first talk was given via Skype with Dr. Robert Hampson from Wake Forest University in North Carolina. WIN55212 suppresses the encoding of new information but does not suppress memory recall. The research supports the role of cannabinoids in learning and memory, modulating the strength of neural encoding for long and short term storage. This research may help develop drugs for the treatment of PTSD or learning disabilities.

Next Marocoita Gilbert  of East Carolina University gave a stunning presentation on the effects of cannabinoids on memory in birds (Finches). Birds and humans learn to communicate through vocal learning, imitating sounds of the parents. In birds the song can be passed down from parents to offspring. WIN55212 reduced the ability of birds to memorize songs, which was directly correlated with a down regulation in an important brain protein known as ARC. These finches tended to improvise the song! In a sense, the finches that were given a cannabinoid would preform jazz instead of classical.

Dr. Jerry Wright Jr.  of Scripps Research Institute conducted a study on the effects of visual memory and learning in monkeys, using pure THC.  The monkeys correct responses were affected by the number of stimuli given to the monkeys. Conceptually, if the monkeys were only doing one task, there was no difference. However, as the number of tasks increased, the monkeys incorrect responses increased. Interestingly, the psychomotor or coordination of monkeys was unaffected in raisin and pellet acquisition tests which required manual dexterity.

The research presentations then focused on pain and inflammation. In short, the following studies showed that Endocannabinoids such as PEA are effective in treating models of arthritis, pain, and inflammation.

Dr. Barbara Costa began by discussing that existing arthritis drugs are restricted to analgesics (pain management) with limited efficacy and lots of side effects. Cannabinoids may represent a reasonable approach to this chronic condition. PEA speeds recovery. Strong decreases could be found in inflammation, pain, and positive increase in peripheral nerves; where arthritis impairs movement. Dr. Costa suggested that endocannabinoids should be compared with a steroid; compared or co-applied with NSAIDS.

James Burton of the University of Nottingham showed that PEA was also able to inhibit immune cell migration, a hallmark of tissue damage and inflammation. Sharleen Yuan from the University of South Dakota complimented the pain research by showing data that outlined the mechanisms modulating EC signaling in neurons.

Ending the first symposium of the ICRS conference, Aron Lichtman from Virginia Commonwealth University shared research on a new drug, JZL184 which shares many properties of THC without motor skill effects.

The second session focused on the effects of cannabinoids on the gut and intestinal disease.

Poly unsaturated fatty acids (PUFAs) are precursors to many important biological factors. Amino acids are thought to form conjugations with fatty acids to mediate important events related to neuro-transmission. Dr. Kitty Verhoeckx shared her team’s discovery of fatty acid serotonins which were able to inhibit the FAAH enzyme, which raises the levels of endocannabinoids in the body. The research studied the effect of various combinations of oils (fish, sunflower) on the metabolism of these N-Acyl serotonins in animals. The production of fatty acid seratonins was directly related to diet.

Erin Rock from the University of Guekph presented research on Cannabidiol (CBD). CBD is usually the second most adundant cannabinoid on the Cannabis plant. CBD does not appear to activate the cannabinoid receptors, CB1 or CB2. Instead CBD appears to interact with serotonin receptors (5HT-1A) to reduce nausea and vomiting. CBD may be an effective anti-nausea and anti-vomiting drugs for cancer patients.

Steven Kinsey of the Virginia Commonwealth University showed that THC could block the formation of gastric hemmorages. Additonally, the protective effect of THC was mimicked by raising endocannabinoids through FAAH inhibition. FAAH is the enzyme that breakdown endocannabinoids. JZL184 knocked down and almost completely blocked hemorrhages, but tolerance developed after 6 days, if larger doses are administered chronically.

Dr. Alhouayek from the University of Louvain shared her work on inflammatory bowl disease (IBD) and cannabinoids. IBD occurs in about 10,000 people a year in developed countries. The root causes of IBD are unknown and a curative therapy remains elusive. Activating CB receptors is protective while blocking the receptors makes Colitis or IBD much worse.  AEA is known for its protective effect but little is known about the effectiveness of 2-AG. Mice with IBD were effectively treated by raising the body’s own natural endocannabinoids, using synthetic compounds known as JZL184 and URB597. Colon tissue was shown to be protected by raising the levels of endocannabinoids. The protective effects were stopped by blocking by CB1 and CB2 receptors. CB1 and CB2 activity is important for a healthy colon. However, it was the elevated levels of the endocannabinoid 2-AG that were thought to be responsible for the beneficial effects.

The day ended with a flurry of cancer research highlighting the effectiveness of CBD to treat wide variety of cancers.

Members of Cristina Sanchez’s and Manuel Guzman’s labs from Spain discussed mechanisms of cancers, demonstrating the role of CB2 and GPR55 in cancer pathogenesis.

Dr. Alessia Ligresti from the Italian Endocannabinoid Research Group looked at 12 different plant cannabinoids and found that CBD was a potent anti-cancer agent against prostate cancer.

Dr. Sean McAllister from the California Pacific Medical Center demonstrated the effectiveness of CBD to treat aggressive cancer cells that were removed from cancer patients.

Lastly, Gabriella Aviello from the University of Naples showed how CBD may prevent or treat colon cancer, one most common and deadliest forms of cancer in the western world.

CBD was the star of the show on opening day here at ICRS, demonstrating potent anti-cancer effects in a variety of cancer types. CBD shows great promise, and may be used in an upcoming clinical trial with breast cancer, organized in part by Dr. Sean McAllister.

Jahan Marcu is currently investigating the pharmacology of cannabinoid receptors. He was working at the California Pacific Medical Center Research Institute when exciting discoveries were made showing enhanced anti-cancer effects with THC and CBD from the Cannabis plant. The findings were published in the Journal of Molecular Cancer Therapeutics. In 2009 he received the Billy Martin Award from the International Cannabinoid Research Society (ICRS). Jahan is currently the vice-chair the Medical and Scientific Advisory Board at Americans for Safe Access (ASA). Questions?   Contact    [email protected]

DISCLAIMER: The views and opinions expressed are those of the author and do not necessarily represent any University, business or affiliates. While the information provided in this blog is from published scientific studies it is not intended to diagnose or treat any disease.

The grassroots resistance movement continues to grow, as these protesters take to the street in Livingston, Michigan, where a dispensary was raided and the owners arraigned on charges they delivered marijuana to an undercover officer posing as a medical marijuana patient.

As a mother of four children, Robin Schneider sympathizes with women who try to provide medical marijuana in a safe, legal place.The Lansing-area woman uses a medical marijuana ointment on her back to relieve chronic pain from a serious fall when she was 19, and she said she won’t travel to a “back alley” to get a substance voters have determined is now legal for limited use in Michigan.

Schneider was one of 15 protesters outside Brighton’s District Court, where a Handy Township couple, who operated a medical marijuana dispensary that was twice raided by police, was being arraigned on charges they delivered marijuana to an undercover officer posing as a medical marijuana patient.

One of the owners, Christi Marshall, is a mother, Schneider noted.

“I’m grateful to them for helping so many people obtain medical marijuana safely,” she said.

Read more.

Amidst an era of medical marijuana proponents and educators suffering at the hands of repeated federal and local crackdowns, one woman holds her own. Her name is Liz McDuffie.

Growing up in Louisiana in the 1950s, Liz McDuffie’s only relief from debilitating migraines was pushing her skull against the headboard of her bed to release pressure. As an adult, the headaches continued to plague her, to the point that her only refuge was a dark room and a bag of ice.

Then, one day in 1969, on the advice of a doctor she met while teaching in Germany, she tried hashish. For the first time, she was able to function without the throbbing pain.
As her headaches subsided, they were replaced with an insatiable curiosity about the medicinal properties of cannabis. The deeper McDuffie dug, the more she realized how much the plant was shrouded in misinformation, despite its 3,000-year history.

After teaching for the U.S. Army and the Pasadena Unified School District, earning a postgraduate degree from USC’s School of Public Administration and running the upscale consignment boutique Ritz Resale, McDuffie shifted her focus. In a self-described “holy endeavor,” she dedicated her life to the one thing that had allowed her to reclaim hers.

“It seemed like it was the only road for me to take,” she says in an accent that still carries hints of Southern twang.

The passionate educator’s energy and determination belie her age. At 70, McDuffie’s petite frame is all the more accentuated as she stands where she’s most comfortable — in front of a classroom full of students. Her copper-streaked hair falls softly around her delicate glasses, but her fervor shines through, with eyes that rarely stray and hands that whirl to emphasize her words.

Her creed, at its core, is that “knowledge is power.”

“It all has to do with education,” she says. “That’s really how you change anything.”

Since 2006, McDuffie has been director of the Medical Cannabis Caregivers Directory, or MCC, a nonprofit center where students learn how to grow, use and sell medical marijuana.

Read more at LA Weekly.

 

Everybody can be great…because anybody can serve. You don’t have to have a college degree to serve. You don’t have to make your subject and verb agree to serve. You only need a heart full of grace. A soul generated by love. ~ Martin Luther King Jr.

Sex work and medical marijuana activism share common ground. Both parties understand that their cause is based on a victimless crime, needlessly stigmatized by society. Both parties have been on the wrong side of the law and have witnessed wasted lives and countless dollars in needless arrests. And both movements benefited immensely from Robyn Few, who passed away on September 12, 2012 from a long struggle with cancer.

Robyn Few, a native of Kentucky, USA, ran away from home at age 13 and later became an exotic dancer. After marrying and having a daughter in her twenties, she began to take college courses in the hopes of earning a degree in theater arts. She went to California in 1993 to pursue theater and become an activist. Acting and activism not being the highest paying jobs, Few turned to prostitution to pay the bills in 1996. She has worked tirelessly as an advocate and caregiver for medical marijuana and AIDS patients and has gained quite a reputation in the Bay Area activist community as an effective lobbyist for the issue. In June of 2002, the FBI arrested Few, under the direction of the U.S. Attorney General John Ashcroft.

Using the Patriot Act, Ashcroft was able to equate terrorism with prostitution and get additional funding for the very expensive investigation. She was convicted on one federal count of conspiracy to promote prostitution and received six months house arrest, which she finished serving in June 2004. Judge Marilyn Hall Patel allowed Few to continue her activism and volunteer efforts while under house arrest.

Dubbed the “patriotic prostitute,” a campaign centered on the idea that prostitution should be decriminalized to protect women from violence began in October 2003 with The Sex Workers Outreach Project. SWOP is an outgrowth of the anger and frustration that Few feels as a result of her federal bust. “Until prostitutes have equal protection under the law and equal rights as human beings, there is no justice. Until prostitutes are no longer criminals why would they come forward and allow themselves to become targets for law enforcement? Decriminalization is the beginning of the solution; it’s not the solution itself” — says Few.

Robyn Few was the Director of SWOP-USA and co-founder of the International Day to End Violence Against Sex Workers, held on December 17th each year. SWOP helps sex workers and their organizations organize to protect their rights and fight against stigmatization and discrimination. It published media manual, citizen lobbying handbook and decriminalization fact sheets. Its volunteers and staff provide consultation on local, national and international campaigns and organize trainings on topics including lobbying, media, action planning, civil disobedience and strategy.

Federal laws are not exactly fun reading that you bring to the beach. The complex language often makes them tough to understand. But we’re pretty sure everyone knows how the US federal government feels about marijuana. It is illegal – Just Say Drug War.

Perhaps they ended prohibition down in Washington DC and never told us? Just in case, the Maine Health and Human Services Committee and New Jersey’s Attorney General Paula Dow are making sure the US Department of Justice reaffirms their position on pot.

US Attorneys in several states have fired off some unsolicited letters on the issue of medical marijuana. These lay out, in excruciating detail, all of the nasty things that could befall an individual or business who grows, distributes or sells medical cannabis; all in compliance with state law.

The reaction on the ground from governors, state legislators and even the non-profit business owners has been mixed.  Rhode Island’s governor Lincoln Chafee put the only approved dispensaries (all three) on hold after receiving a hand-delivered DOJ letter.

This week Maine’s HHS Committee got their response.  It was very much the form-letter that everyone expected. Still, US Attorney Thomas Delahanty’s carefully worded reply is getting a different reaction in Maine.

State Representative Diane Russell (D-Portland), an outspoken advocate for the medical marijuana program, was not surprised.

“Everything has changed in the last few weeks,” said Russell this afternoon. “But the letter is not stirring as much controversy as it could. ”

Home cultivation was already a part of the safe access law, now Maine is opening the first regulated dispensaries in the state. The program is already off paper and into practice, so could the letter put a wrench in the works? Russell doesn’t think so, “Our program is already in place so we would have to actively shut ours down.”

Maine’s governor is Paul LePage, a Republican. Would he bow to the Fed like Gov. Chafee in RI? Again Russell thinks that Maine has a more state’s rights foundation, “He would be hard pressed to cave. If the HHS committee did that it would be a different story.”

Russell added, “The Governor is very supportive on medical marijuana.”

Maine legislators also took an interesting step to protect the privacy of medical cannabis patients: The registry is now on a volunteer basis.  Most cannabis programs are now mandating that patients register and carry a special identification card, something that is not required for pharmaceutical drugs.

New Jersey was the first compassionate use law in America to pass without any provisions to grow at home. NJ patients must access all of their marijuana at one of six Alternative Treatment Centers…after they register and get an ID card. NJ’s law was passed in January 2010 but the actual program is bogged down – not a single patient card has been issued.

Republican Governor Chris Christie, a former US Attorney, has thrown up every hurdle and legal delay he can muster. Make no mistake; in Jersey the big green marijuana buck stops right at Christie. The six ATCs are planning to capitalize at about $300 $200 million.

On April 22, 20011 New Jersey State Attorney General Paul Dow sent a letter to United States Attorney General Eric Holder with some questions about medical marijuana.

Attempts to reach the NJ US Attorney Paul Fishman about any possible reply letter were referred to the press office for the Department of Justice in Washington DC. This is a very interesting move. Fishman may not join the other US Attorneys in their recent rattling of paper sabers. Instead he may be genuine in his expectation for a response from the head office and Attorney General Eric Holder.

There is already intense pressure on DOJ and Holder personally to make some definitive statement on the medical marijuana issue. While Holder seems like he’s in no hurry to talk, Fishman’s response may be a signal that something is coming down the pipe.

Jessica Smith, a spokesperson reached at the Department of Justice said, “We can confirm that the letter [from NJ AG Paul Dow] was received and is under review.”

So what should states do while they wait for DOJ or should they wait at all?

Diane Russell says that Maine is going forward. “I can’t speak for other states but our medical marijuana bill came about through voter referendum. All those Mainers went got out there and went to the polls. They understand that it’s illegal federally too! So they know it’s illegal and when they went to the voting booth they voted for it anyway.”

Russell added with some Maine accent, “We don’t really care where the feds stand.”

The Compassionate Use Medical Marijuana Act of New Jersey also says pretty much the same thing right in the opening paragraphs:

c.     Although federal law currently prohibits the use of marijuana, the laws of Alaska, California, Colorado, Hawaii, Maine, Michigan, Montana, Nevada, New Mexico, Oregon, Rhode Island, Vermont, and Washington and Montana permit the use of marijuana for medical purposes, and in Arizona doctors are permitted to prescribe marijuana.  New Jersey joins this effort for the health and welfare of its citizens2.;

d.    States are not required to enforce federal law or prosecute people for engaging in activities prohibited by federal law; therefore, compliance with this act does not put the State of New Jersey in violation of federal law

Legislators and voters are well aware of the conflict between state and federal law for medical pot. But more important; in New Jersey the law is aware of this fact, putting Dow and Christie on shaky ground. One thing seems very clear – These medical marijuana laws are written and passed for the direct purpose of countering the federal position.

So is there an upside to all of the activity from US Attorneys? Rep. Russell is also working on a full marijuana legalization bill, LD 1453, that would tax recreational cannabis. After initial hearings before the Criminal Justice Committee the bill is still alive. LD 1453 will have to pass both houses then go to voters for approval.

“The one thing that the letter has done is start legislators asking questions,” Russell said today. “And the idea of sending it out for a referendum may actually get it some more votes over here on the hill.”

Maine is not only state on the East Coast with active legislation for fully legal cannabis; A bill was introduced in Massachusetts, HB 1371, to tax and regulate the marijuana market. There are also ballot initiatives in process for 2012 in California, Colorado and Washington.

Based on the sensitivity of the US attorneys regarding the medical cannabis programs, it seems unlikely that they will stay silent about concepts that go even further.

On the ground:

Maine – www.facebook.com/LegalizeMaineFirst

Massachusetts – www.masscann.org

New Jersey – www.cmmnj.org

Questions?  [email protected]

Chris Goldstein is a respected marijuana reform advocate. As a writer and radio broadcaster he has been covering cannabis news for over a decade. He volunteers with local groups to change prohibition laws including PhillyNORML and The Coalition for Medical Marijuana New Jersey.

logo from maine.gov

6/24/2011 – Governor Paul LePage signed a new law today expanding privacy protections for medical cannabis patients in Maine.

“I am pleased that the Legislature has voted to move the law closer to the initiated bill that was enacted by the voters,” said Governor Paul LePage in a statement today. “I am proud to a sign a bill that protects patient privacy and respects the will of the voters.”

Maine voters approved the compassionate use law on a ballot measure in 1999.

The Maine Civil Liberties Union issued a press release today with a statement from the law’s sponsor:

“Researching this program for the last 7 months has been quite an education,” said Representative Deborah Sanderson (R-Chelsea), primary sponsor of the bill.   “I’ve read countless case studies on the benefits of marijuana for many conditions.  What has been the most informative and moving however, has been speaking to the patients themselves.  Folks who suffer chronic debilitating pain and have used opiates, often for months, are seeing better pain management results without the highly addictive results that opiates often have.”

The bill makes registration optional for patients and some caregivers and eliminates the requirement that patients disclose their specific medical condition to the state.  The law also mandates more effective processes for adding approved medical conditions, improves the procedure for minor patient access and prevents municipalities from instituting regulations more restrictive than State Law.   Importantly, patients, caregivers and dispensary employees acting under the law will be protected from arrest, prosecution and discrimination.

Earlier this week we spoke with Jonathan Leavitt who represents medical marijuana interests under the Medical Marijuana Caregivers of Maine trade association.

“This gets the state out of the business of a patient’s health and puts it back in the hands of those patients and their physicians here in Maine,” said Leavitt.

National NORML’s Deputy Director Paul Armentano, a medical marijuana policy expert, commented, “At the same time when lawmakers in many other states are enacting impossibly restrictive measures, Maine lawmakers have elected to instead significantly open patients’ access to medical marijuana under the law.”

Here is a link to the full executive summary.

Chris Goldstein is a respected marijuana reform advocate. As a writer and radio broadcaster he has been covering cannabis news for over a decade. Questions?  [email protected]

UPDATE 6/14/2011- 11:13AM ET – Maine House accepts the “ought not to pass” report from Criminal Justice Committee – bill sent to Senate. 

6/13/2011 – World leaders and even President Obama say that there should be a “legitimate” debate about cannabis prohibition. But this week a body of elected officials may actually engage in that dialogue. The House and Senate in Maine could consider LD 1453, “An Act to Legalize and Tax Marijuana.” The last two days of the legislative session are this week. The bill’s sponsor, Rep. Diane Russell (D-Portland), says that the issue has garnered enough interest among her peers for a floor debate.

Today Russell sent an email to supporters that said, “We have all worked so hard for this to happen and now the day is upon us.”

LD 1453 had a hearing on May 10th before the Criminal Justice Committee where two caveats were added. It must wait to become law until 1) federal policy changes and 2) it is approved by Maine voters directly on the ballot. Those two criteria must be met after LD 1453 passes a floor vote in both houses (outside chance but possible) and is then signed by Governor LePage (less possible). The bill creates careful systems of regulated cultivation, cannabis sales (to adults only) and taxation models.

This week marks the 40th year since President Nixon declared a “War on Drugs” that has largely been fought against marijuana consumers.  A 1972 Presidential Commission presented a report that called for cannabis to be de-scheduled from the Controlled Substances Act and that personal possession should be decriminalized at the federal level. Nixon instead placed marijuana in Schedule I of the Controlled Substances Act and began vigorous enforcement worldwide.

The Global Commission on Drug Policy held a press conference on June 2, 2011 calling for governments to explore new options to replace criminal prohibition. Regulating cannabis was a priority, especially for the former Presidents of Colombia and Brazil.

This week there will be demonstrations, press conferences and vigils commemorating the victims in the 40 years of prohibition. But the live stream from the State House in Maine may be the only chance to see politicians get into the nuts and bolts of crafting a vital solution for cannabis.

Because it is the end of the session, the debate for LD 1453 is not a sure thing. Rep. Russell is asking Maine residents to contact their legislators and support the bill’s open debate. Maine House:  (207) 287-1400 — Maine Senate: (207) 287-1540.

Grassroots link: http://www.facebook.com/LegalizeMaineFirst

Chris Goldstein is a respected marijuana reform advocate. As a writer and radio broadcaster he has been covering cannabis news for over a decade. Questions?  [email protected]

5/11/2011 UPDATE 4:59PM ET – A landmark hearing yesterday in Maine before the Criminal Justice Committee on a bill to tax and regulate recreational marijuana had an interesting outcome: The issue could eventually be decided by Maine residents.  If LD 1453 does pass floor votes in the legislature the bill must also pass a voter referendum to become a  law.

The bill’s sponsor, Rep. Diane Russell of Portland, made the referendum motion and was pleased with the hearings. She has reported a massive surge of public support for Maine’s legalization effort. The media and bloggers have also been focused on the bill, bringing in attention from around the country. For example, the hearing on LD 1453 is the top story right now at Reddit.com.

Rep. Russell said in an email to Freedomisgreen.com today, “I had no idea this would make it to the front page of Reddit literally overnight. The response has been astounding and there have been a remarkable number of interesting and good questions. Not to mention, a ton of support!”

Maine could join California and Colorado as states that are looking to end marijuana prohibition by the end of 2012 with direct participation by voters. All three would create systems of regulated cultivation, sales to adults and taxation systems.

[Editor’s Note – Original post at 4:28PM ET mis-stated that LD 1453 would go  directly to the voter referendum process.]

Maine First Facebook page
http://www.facebook.com/LegalizeMaineFirst

Questions?  [email protected]

Chris Goldstein is a respected marijuana reform advocate. As a writer and radio broadcaster he has been covering cannabis news for over a decade. He volunteers with local groups to change prohibition laws including PhillyNORML and The Coalition for Medical Marijuana New Jersey.